Yeditepe J Dent. 2019; 15(3): 305-310 | DOI: 10.5505/yeditepe.2019.70288

Odontojen kistlerde yað bezi lobulüsü

Nihan Aksakallý
Ýstanbul Üniversitesi, Onkoloji Enstitüsü, Tümör Patolojisi Bilim Dalý, Ýstanbul, Turkey

GÝRÝÞ ve AMAÇ: Dermoid kistlerde bulunan yað bezi lobulüsü odontojen kistlerde enderdir. Dermoid kistler yavaþ büyür ve biyolojik davranýþlarý sesizdir, kist çýkartýldýktan sonra yerel yineleme görülmez. Oysaki bazý geliþimsel odontojen kistler lokal agresif bir klinik gidiþ gösterir, yerel yineleme oranlarý yüksektir; bu tip kistlerde yað bezi lobülüsü bulunabilir. Bu çalýþmanýn amacý yað bezi lobülüsü içeren odontojen kistlerin klinik ve histopatolojik olarak incelenmesidir.
YÖNTEM ve GEREÇLER: Çalýþmada yað bezi lobulüsü içeren 14 odontojen kist olgusunun histopatolojik özellikleri, yað bezi lobulüslerinin sayýsý ve yerleþim özellikleri dikkate alýnarak incelendi. Histokimyasal (PAS) ve immunhistokimyasal (S100 proteini, Pan Sitokeratin, Sitokeratin 19 and EMA ) incelemeleri de yapýldý.
BULGULAR: Çalýþmada 14 olgu incelendi, bunlarýn 9’u erkek (%64), 5’i (%36) kadýndý. 14 odontojen kist olgusunun, 10’u mandibulada, 4’ü maksillada bulunuyordu. Lezyonlarýn hepsi geliþimsel odontojen kistti. Mikroskopik incelemede 11 olguda yað bezi lobulusü yalnýzca fibrotik kist duvarýnda, 1’inde yað bezi lobulüsü epitel içinde yer almýþtý, 2’sinde ise hem epitel içinde, hem epitelin hemen altýnda, hem de fibrotik duvarda izlendi.
TARTIÞMA ve SONUÇ: Bir kistte histopatolojik olarak yað bezi lobulüsü görüldüðünde dermoid kist tanýsý koyulmasý eðilimi vardýr. Bu nedenle ayýrýcý tanýya yað bezi lobulüsü içeren odontojen kistlerin alýnmasý hasta yönetimi ve farklý izlem seçenekleri açýsýndan oldukça önemlidir.

Anahtar Kelimeler: Odontojen kist, intraosseöz dermoid kist, yað bezi, çene kistleri

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Sebaceous glands within odontogenic cysts

Nihan Aksakallý
Istanbul University, Institute of Oncology, Department of Tumour Pathology, Istanbul, Turkey

INTRODUCTION: Sebaceous glands are rarely observed in odontogenic cysts whereas these structures are the histopathologic features of dermoid cysts. Dermoid cyst growth is slow and its biologic behaviour is silent; after the cyst is removed, recurrence is not observed. However, there are some developmental odontogenic cysts that have a local aggressive course and high levels of recurrence and sebaceous glands may present in these types of cyst. The aim of the study is to evaluate the histopathologic and clinical features of odontogenic cyst with sebaceous gland.
METHODS: 14 odontogenic cysts with sebaceous glands were reported in the present study. Histopathological features, locations and numbers of sebaceous glands were evaluated. Histochemical (PAS) and immunohistochemical (S100 protein, Pan Cytokeratin, Cytokeratin 19 and EMA ) examinations were also performed.
RESULTS: In the present study, 14 patients, 9 (64%) male and 5 (36%) female with a mean age of 42 years were included. The cysts were located in the mandible of 10; while four of them were in the maxilla. All lesions were developmental odontogenic cysts. Microscopic evaluation revealed that sebaceous glands were only in the fibrotic cyst wall in 11 cases, in the intraepithelial location in 1 case and 2 cases showed three different sites as intraepithelial, subepithelial and wall.
DISCUSSION AND CONCLUSION: When the sebaceous glands are observed histopathologically, there is a tendency to diagnoisis as a dermoid cyst. Therefore, the differential diagnosis between odontogenic cyst with sebaceous glands and intraosseous dermoid cysts has great importance for management or different follow-up options.

Keywords: Odontogenic cyst, intraosseous dermoid cyst, sebaceous glands, jaw cyst.

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